Bittium NeurOne is an innovative monitoring solution for neuroscience measurements. It is developed for the needs of medical professionals and scientists to detect simultaneously high accuracy neurophysiological signals from multiple channels without compromising data integrity. Bittium NeurOne technology challenges traditional neurophysiological laboratory systems with:
The Bittium NeurOne system is a CE approved class IIa medical device.
By incorporating the latest advances in digital signal processing the Bittium NeurOne Tesla EEG System offers more accuracy, cleaner signals, faster sampling, modular solutions and more flexibility. NeurOne uses a specially developed Tesla amplifier with built in features including high dynamic range and special reduction technology to remove magnetic artifacts for TMS-EEG and fMRI-EEG applications. The NeurOne EEG system is available in 40 to 160 channels consists of a Main Unit and 1 up to 4 Tesla 40 channel amplifiers.
Bittium NeurOne is a versatile system that can be used widely in different neuroscience and psychological applications. Bittium NeurOne™ Tesla is especially designed for use together with transcranial magnetic stimulators having extremely large dynamic range and special reduction technology to remove magnetic artifacts in short latencies. An advanced amplifier design enables using both AC and DC recording modes to be configured per the end-user's preference. The innovative Tesla MRI amplifier brings MRI compatibility to Bittium NeurOne.
The Bittium NeurOne system is designed to be used together with transcranial magnetic stimulators (TMS). High dynamic input range (+/- 430 mV in DC mode and +/-86 mV in AC mode) combined with wide analog band (DC..3500 Hz) keeps TMS induced artifacts short, allowing analysis of brain activations even in short latencies. Additionally, hardware mute function and software based online artifact reduction can be used.
EEG sample synchronized triggering: Triggers generated by the stimulation system (Presentation, Superlab, E-Prime) can be routed through the Bittium NeurOne Main Unit to the TMS device or other simulation device. Bittium NeurOne feeds out a trigger pulse in constant phase with EEG sampling allowing, accurate reproduction of TMS induced artifact for easier artifact removal.
Bittium NeurOne Tesla enables concurrent MRI and EEG measurements. When using the Bittium NeurOne Syncbox EEG acquisition is synchronized with the MRI scanner clock (e.g. 4 or 10 MHz). High dynamic input range (+/- 430 mV in DC mode and +/-86 mV in AC mode) combined with wide analog band (DC..3500 Hz) yields an accurate signal with no risk of saturation when using high gradient strengths.
The Bittium NeurOne system can handle virtually any evoked potential (EP) and event related potential (ERP) measurement task because of its extensive triggering interfaces, amount of measured channels, low noise and high sampling frequency.
EMG research with very high resolution and high amount of channels: The Bittium NeurOne system has up to 32 channels of dedicated bipolar channels for EMG use. The amount of usable channels can be increased even further by also utilizing the referential channels.
Modularity of the system enables measuring up to 4 persons simultaneously on one system with fully synchronized video camera support. When used with our Brainstorm technology (Multi Syncbox) up to 10 Bittium NeurOne hardware systems can be synchronized together allowing 30 amplifiers to run with one clock – all recorded with one computer.
Other neuroscience and psychological measurements: You name the signal, Bittium NeurOne can measure it. Additionally, Bittium can customize the Bittium NeurOne system per your application. Ask for a quote and describe your application.
EEG data can be fed into another application or analyzing computer using the Bittium NeurOne DigiOut Ethernet/UDP option. The Bittium NeurOne system quarantees a minimum delay ( <3 ms and jitter-free transfer). Additionally we have LSL proxy for DigiOut option.
Brain Computer Interface studies are made easy with a BCI2000 driver and Matlab SIMULINK driver.
For real time applications like Closed-loop TMS there is a 16 channels analog out option which allows a very low latency of 2.5 ms. The Optional Real-time Digital Out is also an option.
The video package consists of a camera with HDMI output (+ Mic In for synchronization), USB3 capture box, MPEG-2 codec and a VideoSync unit that sends triggers to the NeurOne EEG stream every 10 seconds. The same trigger is fed to the audio track of the video to allow accurate synchronization throughout the recording.
The data format of Bittium NeurOne is compatible with most popular EEG analysis modalities, including Matlab, EEGLAB, BrainVision Analyzer and BESA.
Triggers generated by the stimulation system (Presentation, Superlab, E-Prime, Matlab real-time system etc.) can be routed through the NeurOne Main Unit to any TMS device (or other devices utilizing a constant wave form). The NeurOne then feeds out a trigger pulse in constant phase to the EEG sampling rate allowing accurate reproduction of the TMS induced artifact for easier artifact removal. Please see Synchronizing the transcranial magnetic pulse with electroencephalographic recordings effectively reduces inter-trial variability of the pulse artefact by Tomasevic et al. 2017
Data delivery is handled by the NeurOne EEG System hardware which allows the data to come out with a small ( < 3 ms) and constant delay important for Brain State or Frequency Dependent TMS applications also Closed-loop TMS. The NeurOne software with the optional Digiout function simultaneously records EEG and feeds the signals as UDP packets from the NeurOne Main Unit Ethernet/Digiout port to real-time systems including Speedgoat and Labview. Please see Real-time EEG-defined excitability states determine efficacy of TMS-induced plasticity in human motor cortex by Zrenner et al. 2018
EEG can be recorded in fMRI studies with the NeurOne Syncbox MRI to synchronize the clock for EEG acquisition to the clock output of the MRI system typically at 10 MHz. Offline analysis can be completed with BESA 7.0 (released in 2018) with 3 methods for artifact correction as published by Allen et al. 2000, Allen et al. 2000 and Moosmann et al. 2009 for fMRI-EEG studies.
The amplifier design guarantees the best possible signal quality. Tesla amplifiers have a DSP (Digital Signal Processor) that takes care of digital filtering and decimation of signals from original data sampled at 80 kHz (and high resolution of 24 bits) to the actual sampling frequency. Data is collected at a high analog bandwidth and high frequency and then the final EEG signal is produced with digital processing (using multistage FIR filtering).
Each amplifier has 32 monopolar referential channels and 8 bipolar channels. Each channel can (individually) be set to operate in AC or DC mode.
|AC Mode||DC Mode|
|Input Range||+/- 86 mV||+/- 430 mV|
|Analog Bandwidth||0.16 Hz-3500 Hz||0 Hz-3500 Hz|
|Noise 0-200Hz||< 0.6 uV RMS||< 0.8 uV RMS|
|Noise Full-band||< 1.5 uV RMS||< 2.0 uV RMS|
|Sensitivity||10.2 nV/bit||51 nV/bit|
|Impedance measurement||1 kΩ to 50 kΩ||1 kΩ to 50 kΩ|
The amplifier is powered with a battery pack. The battery pack allows total electrical isolation of the amplifier from physical environment. Since communication from amplifier to the Main Unit is via optical cable, there is excellent signal quality regardless of the quality of the electricity or grounding of the building. Using the battery also keeps mains frequency (50/60 Hz) out of a shielded room if used.
The main unit acts as a central hub communicating with the amplifiers and the acquisition computer. It is also an isolated connection point for triggers coming from the stimulation/cognitive testing PC. Ethernet connection (TCP/IP) to the acquisition PC gives flexibility since the computer can be located far away from test person if necessary.
Items marked with* are investigational devices and for research use only. CAUTION - Investigational Device. Limited by Federal (or United States) law to investigational use.