neuroConn LOOP-IT*

neuroConn-LOOP-IT*

This hardware platform is perfect for realtime data acquisition, analysis, and the control of neuro-modulatory stimulation. It enables state-dependent and closed-loop controlled experiments, Temporal Interferance stimulation and neuromuscular stimulation - all simultaneously and synchronously and within one box.

LOOP-IT ensures minimized constant delays between data acquisition, analysis, event detection, and derived parameters for the output module (e. g., tES or FES current source, trigger of TMS).

Functioning as a multi-channel stimulator for 2 or 4 transcranial and/or peripheral stimulations, our current sources exhibit low noise, high temporal precision, and galvanic isolation. This setup is specifically designed for temporal interference stimulation as well as pairing transcranial and neuromuscular stimulation, providing a comprehensive solution for advanced neuroscience research.

Research Note: The platform is intended for use in a research context, and its applicability in other practical settings should be evaluated with caution.

Features

Galvanically isolated modules with different functionality:

EEG / ECG / EMG biosignal acquisition (up to 1 ksps)
tDCS / tACS / tRNS current sources (low 1/f noise, < 5 mApp, < 5 kHzbandwidth)
neuromuscular electrical stimulation (NMES) (< 200 kHz, full scale rise time: 1 µs; high-power (+/- 40 mA) and high speed application up to 1 ms duration in constant current applications (+/- 15 mA)
multichannel digital I/O (TMS, event-related potentials)
sensor interface for non-electrical biosignals (e. g. movement, breathing, blood flow, temperature)

Based on a real-time data processing platform

all modules run synchronized
simultaneous read/write-access to all modules
jitter-free data transceiving
loop delay can be set down to 100 μs

Real-time system for physiological oscillations phase-dependent stimulation:

state-dependent and closed-loop controlled experiments in a stable time regimen with 1 - 3 ms turn-around time:
data acquisition of ExG (EEG, ECG, EMG), 3-axis acceleration 24 bit/1 kHz
data analysis of amplitude, frequency, latency, phase
modulation and control of the actuators tES / NMES / TMS

Direct access to hardware parameters via supplied library (Python)

Medical-grade hardware design

Standard interface and compact design

Highlights

Modular platform enables endless combinations of electrically isolated analogue and digital I/O modules
Customized hardware adaptation
Enables true real-time data processing
Guaranteed all modules run synchronized
Minimal jitter data transceiving (30 µs – 50 µs)
Simultaneous read/write-access to all modules

Medical-grade hardware design
Standard interfaces (LSL, USB, TCP/IP, RS232, TTL) and compact design
MRI – compatible TFI / tES
Real time algorithms for closed loop NIBS-EEG
- Fast processing within 1 ms
- No forward prediction necessary (no extrapolation)
All-in-one platform - low cost

Technical Data

Arbitrary EXG biosignal acquisition 1.000 sps / 24 bit
Dynamic range adjustable from +/-2.5V … +/- 104 mV
Interface for EEG-caps, EXG electrodes
Arbitrary In/Out TTL level
Functional Electrical Stimulation module for NMES

Arbitrary independent current sources for TIF or tDCS / tACS / tRNS (low noise, 8 mA, 5 kHz bandwidth - adjusted for co-registration with EEG to avoid systematic errors due to Digital-Analogue-Conversion 40 ksps / 16 bit; low noise, high intensity, very fast)
Additional sensors (xyz, SpO2, BP)

Applications

Conventional applications on TMS

collecting EMG for MEP investigations during TMS for read out on M1
collecting ECG for HR investigations during TMS for read out on DLPFC
collecting EEG for TEPP investigations during TMS for read out on the whole brain

EEG & NIBS (8x EEG, 1x DIO)

towards personalised therapeutic brain-state dependent therapies in rehabilitation and psychiatry

NIBS (2x tES)

Temporal Interference stimulation for enabling targeted structures deep inside the brain by steering the electric fields of maximum amplitude modulation

NIBS & NMES (1x tES, 1x NMES)

Phase-dependent modulation of human corticospinal plasticity by associative pairing of transcranial and neuromuscular stimulation (tES & NMES)

LOOP-IT*: all-in-one solution that sets new standards in neuroscience research lab equipment

Real-time system for physiological oscillation phase-dependent stimulation

A system designed to facilitate state-dependent and closed-loop controlled experiments. This system is engineered to achieve a stable turnaround time, typically within the range of 1-3 ms, though actual performance may vary based on experimental conditions.

Data Acquisition: Capable of acquiring ExG (EEG, ECG, EMG) data and 3-axis acceleration, with a 24-bit resolution at a 1 kHz sampling rate.
Data Analysis: Processes data for amplitude, frequency, latency, and phase analysis.
Modulation Control: Enables modulation through control or trigger mechanisms for tES (transcranial electrical stimulation), NMES (neuromuscular electrical stimulation), and TMS (transcranial magnetic stimulation).

New Current Source Modules for Enhanced Stimulation:

Our recently developed current source modules have expanded the range of electrical stimulation parameters for electrophysiology modulation. These modules provide:

Transcranial Stimulation: Up to ±5 mA (below 5 kHz) with low 1/f noise, designed for use in combined tES and electrophysiological measurements.
Peripheral Stimulation: Capable of high-power stimulation up to ±40 mA at high speed, with pulse lengths up to 1 ms, and constant current applications up to ±15 mA.
Synchronization Capabilities: Facilitates synchronization between transcranial and peripheral stimulation in a single unit, enabling the pairing of current sources.

Conventional applications on TMS

EMG Collection: For MEP (Motor Evoked Potential) investigations during TMS, with readout capabilities on M1 (primary motor cortex).
ECG Collection: For heart rate (HR) investigations during TMS, with readout on DLPFC (dorsolateral prefrontal cortex).
EEG Collection: For TEPP (TMS-Evoked Potential) investigations during TMS, allowing readout across the whole brain.

Utilization of NIBS (2x tES):

Temporal Interference Stimulation: Targeting deep brain structures by controlling the electric fields for maximum amplitude modulation.

Combination of NIBS & NMES (1x tES, 1x NMES):

Phase-Dependent Modulation: Investigating the associative pairing of transcranial and neuromuscular stimulation (tES & NMES) to modulate human corticospinal plasticity.

neuroConn closed-loop solutions for researchers

The simultaneous application of non-invasive brain stimulation (NIBS) and EEG has significantly advanced our comprehension of NIBS-induced local and network effects, as well as the functional role of brain oscillations. The manipulation of individual parameters, such as intensity, frequency, and phase, can influence the outcomes of NIBS. State-dependent NIBS allows researchers to precisely control these parameters and influence brain activity with high temporal and spectral precision.

Accesories References Request for Demo

Accesories

Various accessories for EEG acquisition includes electrodes in different sizes and shapes, along with cables, caps, and conduction pastes. These items are available for both individual and set purchases. For guidance on selecting electrodes appropriate for your project, our team is available to assist.

Accessories and consumables for EEG recording

References

Product data sheet LOOP-IT

neuroConn closed-loop solutions for researchers

Portfolio for research incl. LOOP-IT

Non-invasive brain stimulation and brain imaging

Poster

Real-time system for physiological oscillation phase-dependent stimulation

Poster

Current sources modules for non-invasive modulation of electrophysiology

Items marked with* are investigational devices and for research use only. CAUTION - Investigational Device. Limited by Federal (or United States) law to investigational use.